Evaluation of the anticancer potentials of Origanum marjorana on fibrosarcoma ( HT - 1080 ) cell line
نویسندگان
چکیده
*Corresponding author: Varalakshmi Kilingar Nadumane, Associate Professor, Department of Biotechnology, Centre for Post-Graduate Studies, Jain University, #18/3, 9th Main, III Block, Jayanagar, Bangalore-560 011, India. Tel: 080-43226500 Fax: 08043226507 E-mail: [email protected] Foundation Project: Supported by JGI(Jain Group of Institutions), Project No: SBMJET/CPGS/KNVPJ/09-10.
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Effects of glucocorticoids on the growth of human fibrosarcoma cell line HT-1080.
The human fibrosarcoma cell line HT-1080 exhibits rapid growth following s.c. inoculation in 4-6-week-old male athymic mice. Cytosols from tumors carried in athymic mice bind glucocorticoid (Kd, 1.8 +/- 0.48 X 10(-8) M; Bmax, 240.5 +/- 35.3 fmol/mg cytosol protein, mean +/- SEM). Receptor sediments primarily in the 8-9S region on 5-20% sucrose gradients and is specific for the glucocorticoids. ...
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A human fibrosarcoma cell line, HT-1080, and four new cell lines (HS-16, HS-28, HS-30, and HS-42) were established from untreated patients with mesenchymal chondrosarcoma, peripheral nerve sheath sarcoma, malignant hemangiopericytoma, and mixed mesodermal tumor, respectively, and were used for analysis of mechanisms of intrinsic resistance to methotrexate. All four new cell lines were resistant...
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Pardaxin is an antimicrobial peptide (AMP) that was first isolated from secretions of the Red Sea Moses sole. The role of pardaxin in inducing apoptosis for preventing cancer has not yet been investigated. In the present study, we examined the antitumor activity of pardaxin against human fibrosarcoma HT-1080 cells; pardaxin inhibited cell proliferation by inducing apoptosis, as demonstrated by ...
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